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- Title
刺山柑果实醇提物正丁醇部位提取物抗炎镇痛效果分析.
- Authors
张亚涛; 包晓玮; 曾兰君; ,魏晨业; 何梦梦; 金渭荃
- Abstract
【Objective】 To investigate the anti-inflammatory and analgesic activity of ethanol extracts of Capparis spinosa and n-butanol. 【Method】 Using ultrasonic-assisted extraction method combined with response surface to optimize the optimal ethanol extraction process with the total flavonoids extraction as the index, extract the ethanol extract to obtain the n-butanol fraction. The anti-inflammatory effect of the n-butanol extraction site was investigated using xylene-induced swelling of the auricle of mice and the capillary permeability of the abdominal cavity of the mice; the analgesic effect of the n-butanol extraction site was examined by hot plate method and twisted acetate. 【Results】 The high-dose and medium-dose groups of n-butanol significantly inhibited the auricle swelling induced by xylene in mice (P<0.01); Permeability has a significant inhibitory effect (P<0.01); high-dose and mid-dose groups in the n-butanol area could significantly increase the hot plate pain threshold in mice, and high-dose and middle-dose groups in the n-butanol area could significantly reduce the number of writhing in mice induced by acetic acid (P<0.01). 【Conclusion】 The n-butanol extract of Capparis spinosa fruit has potential anti-inflammatory and analgesic effects.
- Publication
Xinjiang Agricultural Sciences, 2021, Vol 58, Issue 1, p159
- ISSN
1001-4330
- Publication type
Article
- DOI
10.6048/j.issn.1001-4330.2021.01.019