We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Lactobacillus reuteri FYNLJ109L1 Attenuating Metabolic Syndrome in Mice via Gut Microbiota Modulation and Alleviating Inflammation.
- Authors
Yang, Bo; Zheng, Fuli; Stanton, Catherine; Ross, Reynolds Paul; Zhao, Jianxin; Zhang, Hao; Chen, Wei
- Abstract
Metabolic syndrome is caused by an excessive energy intake in a long-term, high-fat and/or high-sugar diet, resulting in obesity and a series of related complications, which has become a global health concern. Probiotics intervention can regulate the gut microbiota and relieve the systemic and chronic low-grade inflammation, which is an alternative to relieving metabolic syndrome. The aim of this work was to explore the alleviation of two different Lactobacillusreuteri strains on metabolic syndrome. Between the two L. reuteri strains, FYNLJ109L1 had a better improvement effect on blood glucose, blood lipid, liver tissue damage and other related indexes than NCIMB 30242. In particular, FYNLJ109L1 reduced weight gain, food intake and fat accumulation. Additionally, it can regulate the gut microbiota, increase IL-10, and reduce IL-6 and tumor necrosis factor-α (TNF-α), as well as liver injury, and further reduce insulin resistance and regulate lipid metabolism disorders. In addition, it could modulate the gut microbiota, particularly a decreased Romboutsia and Clostridium sensu stricto-1, and an increased Acetatifactor. The results indicated that FYNLJ109L1 could improve metabolic syndrome significantly via alleviating inflammation and gut microbiota modulation.
- Subjects
GUT microbiome; LACTOBACILLUS reuteri; METABOLIC syndrome; INSULIN resistance; LIPID metabolism disorders; PROBIOTICS
- Publication
Foods, 2021, Vol 10, Issue 9, p2081
- ISSN
2304-8158
- Publication type
Article
- DOI
10.3390/foods10092081