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- Title
ERAP1 AND HLA-B GENES POLYMORPHISM RELATED WITH ANKYLOSING SPONDYLATIS IN IRAQI PATIENTS.
- Authors
Al-Qiam, Zahraa H.; Al-Saadi, Ali H.; Al-Kazaz, Ali A.; Al-Terehi, Mona
- Abstract
Ankylosing spondylitis (AS) is a common inflammatory disease that causes important structural and functional impairment in the axial skeleton. The etiology of AS is determined by a strong genetic predisposition in combination with the interaction of certain, environmental and geographical factors. The present Molecular study technique In house PCR-SSP was used to determine. The presence of 149bp specific band with control band on 2% agarose gel showed B*27 positivity in Iraq patient ware high significantly than control group, The frequency of HLA- B*27 was found to be significantly increased in patients (O.R 11.27: P value < 0.0001). PCR-SSCP and Sequencing technique determined the genotypes of Significant ERAP1 single marker association with AS susceptibility was found for SNPs namely (rs27044), the polymorphism C → G showed by used PCR-SSCP and Sequencing technique significant difference in genotype polymorphisms between patients and control, this SNP Candidate risk factor with AS patient in Iraq.
- Subjects
ANKYLOSING spondylitis treatment; GENETIC polymorphisms; ENDOPLASMIC reticulum; MAJOR histocompatibility complex genetics; POLYMERASE chain reaction
- Publication
Biochemical & Cellular Archives, 2018, Vol 18, Issue 1, p121
- ISSN
0972-5075
- Publication type
Article