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- Title
CORRELATIONS BETWEEN VASCULAR ENDOTHELIAL GROWTH FACTOR EXPRESSION AND COLORECTAL CANCER.
- Authors
Jalba, C. S.; Jalba, B. A.; Vladoi, Anca-Daniela; Zlatian, O.; Ioana, M.; Bârcă, Amelia; Cimpoeru, Alina; Cruce, M.
- Abstract
To study the expression status and clinical relevance of vascular endothelial growth factor- A (VEGF-A) in colorectal cancer (CRC) tissues. VEGF-A expression was investigated by immunohistochemistry in 89 cases with CRC. Some demographic and histopathologic variables were compared with VEGF-A expression to determine the prognostic significance in CRC. VEGF-A (-) was found in 24 cases; (+), (++) and (+++) stainings were detected in 24, 35 and 6 cases, respectively. VEGF-A (-) was found in 20 of 58 cases with left colon cancer, while only 4 of 31 cases with right colon cancer were VEGF-A (-)(P = 0.024). There was a trend for lower tumor grade and lesser serosal invasion in cases with VEGF-A (-) samples (P = 0.07 and P = 0.079, respectively). Although the correlation was not statistically significant, there was a trend for lower death rate in cases with VEGF-A (-) tumor (P = 0.087). The longest survival was found in cases with VEGF-A (-) tumor and the shortest survival was found in cases with VEGF-A (+++) tumor. Median survival for patients with VEGF-A (-), (+), (++) and (+++) tumors was 59, 47, 35 and 11 months, respectively (P = 0.02). The Cox proportional hazards model identified stage IV disease and VEGF-A (+++) tumor as having the most important influences upon overall survival (odds ratio: 5.1, 95% confidence interval: 2.0-13.0 and odds ratio: 3.6, 95% confidence interval: 1.0-12.7, respectively), followed by serosal invasion (odds ratio: 2.4, 95% confidence interval: 1.0-5.9). This study shows that VEGF-A is a poor prognostic factor in cases with CRC but the relatively small size of the study group precluded the correlation with all the known prognostic indicator.
- Subjects
VASCULAR endothelial growth factors; COLON cancer; IMMUNOHISTOCHEMISTRY; HUMAN research subjects; DEATH rate
- Publication
Annals of the Romanian Society for Cell Biology, 2010, Vol 15, Issue 2, p300
- ISSN
2067-3019
- Publication type
Article