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- Title
Combination of inflammatory and vascular markers in the febrile phase of dengue is associated with more severe outcomes.
- Authors
Nguyen Lam Vuong; Phung Khanh Lam; Damien Keng Yen Ming; Huynh Thi Le Duyen; Nguyet Minh Nguyen; Dong Thi Hoai Tam; Kien Duong Thi Hue; Chau, Nguyen V. V.; Ngoun Chanpheaktra; Chai See Lum, Lucy; Pleités, Ernesto; Simmons, Cameron P.; Rosenberger, Kerstin D.; Jaenisch, Thomas; Bell, David; Acestor, Nathalie; Halleux, Christine; Olliaro, Piero L.; Wills, Bridget A.; Geskus, Ronald B.
- Abstract
Background: Early identification of severe dengue patients is important regarding patient management and resource allocation. We investigated the association of 10 biomarkers (VCAM-1, SDC-1, Ang-2, IL-8, IP-10, IL-1RA, sCD163, sTREM-1, ferritin, CRP) with the development of severe/moderate dengue (S/MD). Methods: We performed a nested case-control study from a multi-country study. A total of 281 S/MD and 556 uncomplicated dengue cases were included. Results: On days 1–3 from symptom onset, higher levels of any biomarker increased the risk of developing S/MD. When assessing together, SDC-1 and IL-1RA were stable, while IP-10 changed the association from positive to negative; others showed weaker associations. The best combinations associated with S/MD comprised IL-1RA, Ang-2, IL-8, ferritin, IP-10, and SDC-1 for children, and SDC-1, IL-8, ferritin, sTREM-1, IL-1RA, IP-10, and sCD163 for adults. Conclusions: Our findings assist the development of biomarker panels for clinical use and could improve triage and risk prediction in dengue patients. Funding: This study was supported by the EU's Seventh Framework Programme (FP7-281803 IDAMS), the WHO, and the Bill and Melinda Gates Foundation
- Subjects
BILL &; Melinda Gates Foundation; EUROPEAN Union; DENGUE; FERRITIN; ADULTS; BIOMARKERS; C-reactive protein; RESOURCE allocation; ARBOVIRUS diseases
- Publication
eLife, 2021, p1
- ISSN
2050-084X
- Publication type
Article
- DOI
10.7554/eLife.67460