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- Title
Nail Psoriasis: A Review of Effective Therapies and Recommendations for Management.
- Authors
Hadeler, Edward; Mosca, Megan; Hong, Julie; Brownstone, Nicholas; Bhutani, Tina; Liao, Wilson
- Abstract
Nail psoriasis has a prevalence that ranges from 10 to 82% and can significantly impact the quality of life of patients. Nail psoriasis is one of the most challenging areas to treat, and multiple therapies have been explored. Topical and injectable therapies are recommended for few-nail disease. Systemic therapies, including biologics, can be considered for patients with multiple and resistant nail disease, impaired quality of life, and severe skin and joint involvement, due to their long-term efficacy. Although outcome data are difficult to compare, interleukin (IL)-17 inhibitors may have superior short-term efficacy when compared to IL-23 inhibitors and tumor necrosis factor (TNF)-alpha inhibitors, although long-term efficacy is similar to TNF-alpha inhibitors. IL-23 inhibitors and TNF-alpha inhibitors have a similar efficacy for nail psoriasis.
- Subjects
NAIL diseases; TUMOR necrosis factors; PSORIASIS; QUALITY of life
- Publication
Dermatology & Therapy, 2021, Vol 11, Issue 3, p799
- ISSN
2193-8210
- Publication type
Article
- DOI
10.1007/s13555-021-00523-x