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- Title
Evaluation of tissue reaction to freshly mixed endodontic sealers and their relationship with the M1 macrophage phenotype.
- Authors
Gomes MOURA, Camilla Christian; MIYAGAKI, Daniela Cristina; Veloso Carvalho de OLIVEIRA, Maria Antonieta; Bertulucci Rocha RODRIGUES, Denise; DECHICHI, Paula; BIFFI, João Carlos Gabrielli
- Abstract
Introduction: This study assessed tissue response to freshly mixed sealers (Sealer 26 - SE26 and Epiphany - EPH) and the relationship between M1 macrophages and tissue repair. Methods: A total of 21 rats were used to assess tissue response at 7, 14 and 21 days post-implantation. Half of histopathological sections were labeled with anti-iNOS antibodies (M1 macro-phage subset) and half were graded according to the inflammatory intensity. Results: On day 7, no significant difference was found in the intensity of the inflammatory reaction between sealers. On days 14 and 21, SE26 showed a more intense inflammatory reaction than EPH (P < 0.05). On days 7 and 14, the number of iNOS+ cells was statistically higher for EPH than SE26 (P < 0.05). Conclusions: SE26 was more toxic than EPH. The degree of inflammation observed in EPH had an inverse relationship with the amount of M1 macrophages observed.
- Subjects
PIT &; fissure sealants (Dentistry); DENTAL adhesives; DENTAL resins; IMMUNOGLOBULINS; MACROPHAGES
- Publication
Dental Press Endodontics, 2014, Vol 4, Issue 3, p14
- ISSN
2178-3713
- Publication type
Article
- DOI
10.14436/2178-3713.4.3.014-020.oar