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- Title
Emergence of Resistance to Colistin During the Treatment of Bloodstream Infection Caused by Klebsiella pneumoniae Carbapenemase–Producing Klebsiella pneumoniae.
- Authors
Kanwar, Anubhav; Marshall, Steven H; Perez, Federico; Tomas, Myreen; Jacobs, Michael R; Hujer, Andrea M; Domitrovic, T Nicholas; Rudin, Susan D; Rojas, Laura J; Kreiswirth, Barry N
- Abstract
We report the emergence of colistin resistance in Klebsiella pneumoniae carbapenemase (KPC)–producing Klebsiella pneumoniae after 8 days of colistin-based therapy, resulting in relapse of bloodstream infection and death. Disruption of the mgrB gene by insertion of a mobile genetic element was found to be the mechanism, which was replicated in vitro after exposure to subinhibitory concentrations of colistin and meropenem.
- Publication
Open Forum Infectious Diseases, 2018, Vol 5, Issue 4, pN.PAG
- ISSN
2328-8957
- Publication type
Article
- DOI
10.1093/ofid/ofy054