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- Title
Immunohistochemical Confirmation of Vulvular Dermatofibrosarcoma Protuberans.
- Authors
Myo Thet Tin; Phoo Ngon Ko Ko; Soe Lwin; Tin Moe Nwe; Than Than Htwe
- Abstract
Introduction: Dermatofibrosarcoma protuberans (DFSP) is a low-to-intermediate grade soft tissue sarcoma of dermal origin having a high local recurrence rate. It usually affects adults between the age group of second and fifth decade. It usually involves the trunk, proximal extremities, head, and neck regions rather than at the vulva region. It is clinically significant being having a high local recurrence rate. The study aims to find out and discuss on the literature review regarding this tumour occurring in a rare location. Method: We presented a case of DFSP from a 54-year-old married woman with an exophytic mass at the vulvar region. Multiple sectioning including its surgical margins were thoroughly performed. Histopathological examination with conventional H&E stain as well as immunohistochemical (IHC) procedure using CD 34 stain was applied for the confirmation and differentiation from other possible spindle cell tumours. Result: We were able to identify a highly cellular lesion running in sheets and parallel bundles. At a first glance it appeared like a spindle cell lesion originated from either smooth muscles or fibrous tissue. Hence, we proceeded with CD34 IHC stain to confirm and exclude other possible differentials. A strong positivity to CD 34 IHC of the lesion was observed. A thorough pathologic assessment with multiple sectioning is an absolute necessity in reporting DFSP occurring in an uncommon region. It is also necessary to express the clearance of its surgical margins to help avoid potential recurrence of the lesion. Conclusion: The role of immunohistochemistry is an essential procedure in confirmation of DFSP from other possible spindle cell tumours: both benign and malignant lesions
- Subjects
HEMATOXYLIN &; eosin staining; LITERATURE reviews; SURGICAL margin; SARCOMA; MARRIED women
- Publication
Malaysian Journal of Medicine & Health Sciences, 2024, Vol 20, p62
- ISSN
1675-8544
- Publication type
Case Study