We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Ageing and colony-forming efficiency of human hair follicle keratinocytes.
- Authors
Lecardonnel, Jennifer; Deshayes, Nathalie; Genty, Gaïanne; Parent, Nathalie; Bernard, Bruno A.; Rathman‐Josserand, Michelle; Paris, Maryline
- Abstract
The decline of tissue regenerative potential of skin and hair is a hallmark of physiological ageing and may be associated with age-related changes in tissue-specific stem cells and/or their environment. Human hair follicles (h HF) contain keratinocytes having the property of stem cells such as clonogenic potential. Growth capacity of h HF keratinocytes shows that most of the colony-forming cells are classified as holoclones, meroclones or paraclones when analysed in a clonal assay ( Cell, Volume 76, page 1063). Despite the well-known impact of ageing on human hair growth, little is known about changes in h HF keratinocyte clonogenic potential with age. This study aimed at assessing the clone-forming efficiency ( CFE) of h HF keratinocytes from three age groups of human donors. It demonstrates that ageing affects h HF keratinocyte CFE.
- Subjects
KERATINOCYTES; HAIR analysis; HAIR follicle physiology; STEM cells; CELLULAR aging; CELL growth
- Publication
Experimental Dermatology, 2013, Vol 22, Issue 9, p604
- ISSN
0906-6705
- Publication type
Article
- DOI
10.1111/exd.12204