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- Title
The endometrial microbiota of women with or without a live birth within 12 months after a first failed IVF/ICSI cycle.
- Authors
Bui, Bich Ngoc; van Hoogenhuijze, Nienke; Viveen, Marco; Mol, Femke; Teklenburg, Gijs; de Bruin, Jan-Peter; Besselink, Dagmar; Brentjens, Linda Stevens; Mackens, Shari; Rogers, Malbert R. C.; Steba, Gaby S.; Broekmans, Frank; Paganelli, Fernanda L.; van de Wijgert, Janneke H. H. M.
- Abstract
The endometrial microbiota composition may be associated with implantation success. However, a 'core' composition has not yet been defined. This exploratory study analysed the endometrial microbiota by 16S rRNA sequencing (V1–V2 region) of 141 infertile women whose first IVF/ICSI cycle failed and compared the microbiota profiles of women with and without a live birth within 12 months of follow-up, and by infertility cause and type. Lactobacillus was the most abundant genus in the majority of samples. Women with a live birth compared to those without had significantly higher Lactobacillus crispatus relative abundance (RA) (p = 0.029), and a smaller proportion of them had ≤ 10% L. crispatus RA (42.1% and 70.4%, respectively; p = 0.015). A smaller proportion of women in the male factor infertility group had ≤ 10% L. crispatus RA compared to women in the unexplained and other infertility causes groups combined (p = 0.030). Women with primary infertility compared to secondary infertility had significantly higher L. crispatus RA (p = 0.004); lower proportions of them had ≤ 10% L. crispatus RA (p = 0.009) and > 10% Gardnerella vaginalis RA (p = 0.019). In conclusion, IVF/ICSI success may be associated with L. crispatus RA and secondary infertility with endometrial dysbiosis, more often than primary infertility. These hypotheses should be tested in rigorous well-powered longitudinal studies.
- Subjects
INTRACYTOPLASMIC sperm injection; MALE infertility; FERTILIZATION in vitro; HUMAN embryo transfer; HUMAN microbiota; HUMAN in vitro fertilization; EMBRYO implantation
- Publication
Scientific Reports, 2023, Vol 13, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-023-30591-2