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- Title
Influence of apolipoprotein E genotype on the response to caloric restriction in type 2 diabetic patients with hyperlipidaemia.
- Authors
Tamasawa, N.; Murakami, H.; Yamato, K.; Matsui, J.; Tanabe, J.; Suda, T.
- Abstract
Aims: Hyperlipidaemia is a major predisposing factor to atherosclerosis in patients with type 2 diabetes. Apolipoprotein (apo) E polymorphism influences lipoprotein metabolism, and the present study was undertaken to explore the relation, in type 2 diabetics, between apo E genotype and the plasma lipid response to dietary therapy. Methods: The subjects were 104 patients with type 2 diabetes and hyperlipidaemia, and the difference, due to apo E genotype, in dietary response was followed for 4–6 weeks. The caloric intake was maintained in the range 20–25 kcal/kg, and the medications for diabetes were not changed during the follow-up period. Results: Plasma total cholesterol (TC) and triglyceride (TG) levels were significantly lowered by the dietary treatment in patients with apo E genotypes of ε3/3, ε2/3 and ε3/4; however, the lipid levels in patients with ε2/4 did not respond to the diet. Conclusions: apo E genotype should be taken into consideration in the treatment of hyperlipidaemia in diabetic patients.
- Subjects
APOLIPOPROTEIN E; TYPE 2 diabetes; HYPERLIPIDEMIA
- Publication
Diabetes, Obesity & Metabolism, 2003, Vol 5, Issue 5, p345
- ISSN
1462-8902
- Publication type
Article
- DOI
10.1046/j.1463-1326.2003.00286.x