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- Title
Two missense mutations in exon 9 of caprine PRLR gene were associated with litter size.
- Authors
Hou, J. X.; An, X. P.; Han, P.; Peng, J. Y.; Cao, B. Y.
- Abstract
Guanzhong ( n = 321) and Boer ( n = 191) goat breeds were used to detect single nucleotide polymorphisms ( SNPs) in the coding regions of the prolactin receptor ( PRLR) gene by DNA sequencing and PCR-RFLP. Two SNPs (c.1457G>A and c.1645G>A) were identified that caused amino acid variations p.Ser485Asn and p.Val548Met respectively. Statistical results indicated that the c.1457G>A and c.1645G>A SNPs were significantly associated with litter size in Boer and Guanzhong goat breeds. Further analysis revealed that combined genotype C4 ( GGGG) and haplotype G-G were better than the others for litter size in both goat breeds. These results might contribute to goat genetic resources and breeding.
- Subjects
MISSENSE mutation; ANIMAL litters; GOAT breeds; SINGLE nucleotide polymorphisms; PROLACTIN receptors
- Publication
Animal Genetics, 2015, Vol 46, Issue 1, p87
- ISSN
0268-9146
- Publication type
Article
- DOI
10.1111/age.12223