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- Title
Therapeutic Hotline: Cysteinyl leukotriene receptor antagonist montelukast in the treatment of atopic dermatitis.
- Authors
Broshtilova, Valentina; Gantcheva, Mary
- Abstract
Leukotrienes are potent proinflammatory mediators derived from arachidonic acid through the 5-lipoxygenase pathway. Experimental data suggest a role for cysteinyl leukotrienes in the pathogenesis of atopy giving a rationale for its use in asthma, allergic rhinitis, and chronic urticaria management. A few clinical observations and small trials suggest that montelukast may be used in an adjunctive manner as an effective therapeutic option for all age categories affected by moderate-to-severe atopic dermatitis. Our own observations proved that montelukast as a prospective corticosteroid-sparing option in the complex therapeutic strategy of corticosteroid-dependent atopic dermatitis patients, even in the severe erythrodermic cases.
- Subjects
ATOPIC dermatitis treatment; LEUKOTRIENE antagonists; ARACHIDONIC acid; ALLERGIC rhinitis; INFLAMMATORY mediators; ADRENOCORTICAL hormones
- Publication
Dermatologic Therapy, 2010, Vol 23, Issue 1, p90
- ISSN
1396-0296
- Publication type
Article
- DOI
10.1111/j.1529-8019.2009.01295.x