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- Title
The protective effects of Gastrodia elata Blume extracts on middle cerebral artery occlusion in rats.
- Authors
Seok, Pu Reum; Oh, Su Jin; Choi, Jin Woo; Lim, Cho Rong; Choi, Jong Ryeol; Kim, Jung Hoan; Shin, Jae-Ho
- Abstract
To investigate the effects of Gastrodia elata Blume (GEB) and 4-hydroxybenzyl alcohol (HBA) on brain damage, GEB or HBA was administered orally for 14 days before middle cerebral artery occlusion (MCAO). After 24 h reperfusion, the proportion of circling was significantly reduced in the GEB (79%) or HBA (69%) group compared to the MCAO group (100%) in the corner test, and the removal time in the adhesive removal test was significantly decreased in the GEB (117 ± 21.0 s) and HBA (101 ± 20.9 s) groups compared to the MCAO group (161 ± 12.6 s). GEB treatment significantly reduced infarct volume compared to the MCAO group. In the GEB and HBA group, necrosis of nerve cells in hippocampus and cortex, expressions of TNF-α and TUNEL positive cells were significantly reduced compared to the MCAO group. These results suggest that GEB and HBA prevents brain damage by anti-inflammatory and anti-apoptotic effects.
- Publication
Food Science & Biotechnology, 2019, Vol 28, Issue 3, p857
- ISSN
1226-7708
- Publication type
Article
- DOI
10.1007/s10068-018-0516-9