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- Title
COMPARISONS OF THE ACCURACY OF THINPREP® PROCESSED WASH AND BRUSH SAMPLES, AND TRANSBRONCHIAL LUNG BIOPSY IN THE DIAGNOSIS OF SMALL CELL LUNG CARCINOMA.
- Authors
Duggan, Máire A.; Cheng Wang; Qiuli Duan
- Abstract
Purpose: The diagnostic accuracy of small cell lung carcinoma (SCLC) using combinations of Thinprep® bronchial wash and brush cytology, plus or minus a transbronchial lung biopsy (TBLB) is unknown. Study Design and Methods: Wash, brush and biopsy specimens from subjects with SCLC and without lung cancer (Negative) were identified by linking laboratory and Cancer Registry files. Subjects were subdivided based on whether they had 1 diagnostic wash or brush (A) or both specimens (B). Worst diagnoses based on: #1) 1 wash or brush, #2) 1 wash and brush, #3) 1 wash or brush plus TBLB and #4) 1 wash and brush plus TBLB were compared to the Registry status. Sensitivity, specificity, positive (PPV) and negative (NPV) predictive value estimates were calculated. Results: Group A SCLC had 24 subjects and Group B 99. Group A Negative numbered 577 and Group B 238. Sensitivity was highest when cytology was combined with TBLB and highest at 80% with a combination of 1 concurrent wash, brush and TBLB. This combination also had the best overall Specificity, PPV and NPV (>92%). Conclusions: One Thinprep® wash and concurrent brush sample plus a TBLB are an optimal combination to diagnose SCLC and exclude those without lung cancer.
- Publication
Canadian Journal of Pathology, 2016, Vol 8, Issue 3, p36
- ISSN
1918-915X
- Publication type
Article