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- Title
Serum Levels of Angiopoietin-2, but not Angiopoietin-1, are Elevated in Patients with Erythrodermic Cutaneous T-cell Lymphoma.
- Authors
Makiko KAWAGUCHI; Makoto SUGAYA; Hiraku SUGA; Tomomitsu MIYAGAKI; Hanako OHMATSU; Hideki FUJITA; Yoshihide ASANO; Yayoi TADA; Takafumi KADONO; Shinichi SATO
- Abstract
Angiogenesis is a crucial process in the growth and progression of cancer, correlating with the metastatic potential of tumour cells. Angiopoietins are ligands for the endothelium-specific tyrosine kinase Tie2 receptor, which comprise 4 structurally related proteins, termed angiopoietin (Ang)-l, Ang-2, Ang-3 and Ang-4. The roles of Ang-1 and Ang-2 have recently been clarified as crucial in angiogenesis. In this report, we measured serum Ang-1 and Ang-2 levels in patients with cutaneous T-cell lymphoma (CTCL). Serum levels of Ang-2, but not Ang-1, in patients with Sézary syndrome were significantly higher than those in patch mycosis fungoides (MF), plaque/tumour MF, and healthy controls. In patients with CTCL, serum Ang-2 correlated with disease activity. Moreover, the numbers of Ang-2+ cells in lesional skin of CTCL were significantly larger than those in normal skin. These results suggest that Ang-2 may have important roles in the development of CTCL.
- Subjects
NEOVASCULARIZATION; ANGIOPOIETIN-2; ANGIOPOIETIN-1; T-cell lymphoma; SKIN cancer
- Publication
Acta Dermato-Venereologica, 2014, Vol 94, Issue 1, p9
- ISSN
0001-5555
- Publication type
Article
- DOI
10.2340/00015555-1633