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- Title
A rare case of isoniazid mono-resistant tuberculosis presenting as cardiac tamponade along with an anterior mediastinal mass in a 15-year-old immunocompetent patient.
- Authors
Mishra, Richa; Jamwal, Ashima; Gupta, Bishal; Kumar, Sudeep; Bharali, Abhijeet; Das, Parijat; Nath, Alok; Jain, Manoj; Neyaz, Zafar
- Abstract
A 15-year-old boy presented with a sudden onset of breathlessness for 7 days, gradual loss of weight of 17.6 lbs over the last month and progressive hoarseness of voice for 7 months. The contrast-enhanced computed tomography (CECT) scan revealed a heterogeneously enhancing lesion in the anterior mediastinum with multiple discrete lymph nodes in the cervical and mediastinal locations. The GeneXpert MTB/RIF assay performed on the CT-guided biopsy of the mass was negative, but the culture for Mycobacterium tuberculosis was positive at 7 weeks of incubation. There was a suboptimal radiological response after 6 months of treatment. First-line drug susceptibility testing (DST) performed by line probe assay (LPA) on the positive culture detected high-level resistance to isoniazid. The treatment was modified as per DST results to which the patient responded well.
- Subjects
MEDIASTINAL tumors; CARDIAC tamponade; ISONIAZID; TUBERCULOSIS; MYCOBACTERIUM tuberculosis; SPINAL tuberculosis
- Publication
Lung India, 2024, Vol 41, Issue 2, p130
- ISSN
0970-2113
- Publication type
Article
- DOI
10.4103/lungindia.lungindia_221_23