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- Title
A multicenter study on the safety and efficacy of bronchial thermoplasty in adults with severe asthma.
- Authors
Madan, Karan; Suri, Tejas; Mittal, Saurabh; Maturu, Venkata; Pattabhiraman, V; Mohan, Anant; Srinivasan, Arjun; Sivaramkrishnan, Mahadevan; Prasad, K; Agarwal, Ritesh; Tiwari, Pawan; Hadda, Vijay; Mehta, Ravindraz; Guleria, Randeep
- Abstract
Background and Aim: Bronchial thermoplasty (BT) is a treatment option for patients with severe asthma. BT involves controlled delivery of radiofrequency energy using a bronchoscopic catheter, thereby reducing bronchial hyperreactivity. Herein, we describe our experience on the safety and efficacy of BT in severe asthma. Methods: This was a retrospective multicenter study of subjects who underwent BT at four centers across India. Results: We included 36 subjects (mean ± standard deviation [SD] age, 50.9 ± 11.5 years, women [69.44%]) undergoing 105 BT treatment sessions. All the subjects met the American Thoracic Society/European Respiratory Society criteria for severe asthma, 22.2% were requiring oral maintenance glucocorticoids. The mean ± SD baseline %predicted forced expiratory volume in one second (FEV1) was 62.07 ± 18.54. The median interquartile range (IQR) annual asthma exacerbation rate in the year preceding BT was 3.5 (1–10). We encountered intraprocedural complications in 7 (6.7%) sessions. An exacerbation of asthma following BT occurred in 6 (5.7%) procedures. We observed a significant improvement in the asthma control test and the asthma control questionnaire scores following BT. The quality of life (asthma quality of life questionnaire) also significantly improved. We noted a significant reduction in the number of exacerbations following BT (median [IQR], 3 [1–10] per year pre-BT versus 0.5 [0–3] per year post-BT, P < 0.001). No significant change occurred in the %predicted FEV1 following BT. Conclusion: BT is a feasible treatment option in patients with severe asthma. More extensive studies are required to establish the efficacy of BT in real-life settings.
- Subjects
INDIA; AMERICAN Thoracic Society; ASTHMA; ADULTS; BRONCHIAL spasm; ASTHMATICS; QUALITY of life; WHEEZE
- Publication
Lung India, 2021, Vol 38, Issue 6, p524
- ISSN
0970-2113
- Publication type
Article
- DOI
10.4103/lungindia.lungindia_741_20