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- Title
Delayed Start Protocol with Gonadotropinreleasing Hormone Antagonist in Poor Responders Undergoing In Vitro Fertilization: A Randomized, Doubleblinded, Clinical Trial.
- Authors
Zarei, Afsoon; Parsanezhad, Mohammad Ebrahim; Kutenaei, Maryam Azizi; Jahromi, Bahia Namavar; Esfahani, Parastoo Soheil; Bakhshaei, Pardis
- Abstract
Objectives: We sought to determine the effects of the delayed start protocol with gonadotropin-releasing hormone (GnRH) antagonists in poor responders undergoing in vitro fertilization (IVF). Methods: This randomized clinical trial was conducted during a 15-month period from April 2014 to July 2015 in clinics in Shiraz, Iran. A total of 42 poor responders with primary infertility were randomly assigned to the controlled ovarian stimulation group utilizing the delayed start protocol (n = 21) or the traditional group (n = 21) using GnRH antagonist, Cetrotide. The primary endpoint was the number of patients undergoing oocyte pick-up, implantation, and the rate of pregnancy. Results: The baseline characteristics of the two study groups were comparable including age, infertility duration, and body mass index. The number of follicles measuring > 13 mm in diameter (p = 0.057), retrieved oocytes (p = 0.564), mature metaphase II oocytes (p = 0.366), embryos (p = 0.709), and transferred embryos (p = 0.060) were comparable between the two groups. The number of patients undergoing oocyte pickup (p = 0.311), the rates of implantation (p = 0.407), and pregnancy (p = 0.596) were also comparable between the two groups. Conclusions: The delayed start protocol was not associated with better conception results or cycle outcomes in poor responders with primary infertility undergoing IVF cycles.
- Subjects
IRAN; LUTEINIZING hormone releasing hormone antagonists; FERTILIZATION in vitro; OVARIAN follicle; INFERTILITY; EVALUATION of medical care; MEDICAL protocols; INDUCED ovulation; OVUM; PREGNANCY; STATISTICAL sampling; EMBRYOS; BODY mass index; RANDOMIZED controlled trials; BLIND experiment
- Publication
Oman Medical Journal, 2018, Vol 33, Issue 6, p506
- ISSN
1999-768X
- Publication type
Article
- DOI
10.5001/omj.2018.92