We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cyclooxygenase-2 Inhibitors in Human Skeletal Fracture Healing.
- Authors
Daluiski, Aaron; Ramsey, Keri E.; Yuexian Shi; Bostrom, Mathias P.; Nestor, Bryan J.; Martin, George; Hotchkiss, Robert; Stephan, Dietrich A.
- Abstract
This article identifies the underlying molecular events responsible for fracture nonunions in a subset of fracture patients. Expression profiling of fracture callus tissue from both uneventful fracture repair and nonunion outcomes showed a decrease of COX-2 expression and an inability to mount an immune response in nonunion fractures. Validation in vitro with Saos-2 osteoprogenitor cell lines showed a decrease in osteogenesis potential after the cells were treated with celecoxib, a COX-2 specific inhibitor and anti-inflammatory agent. This article recapitulates that an initial immune response is crucial to fracture healing and suggests limited usage of COX-2 inhibitors in patients with healing fractures.
- Subjects
CYCLOOXYGENASE 2 inhibitors; CELECOXIB; BONE fractures; BONE injuries; IMMUNE response
- Publication
Orthopedics, 2006, Vol 29, Issue 3, p259
- ISSN
0147-7447
- Publication type
Article