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- Title
Acute selective bioactivity of grape seed proanthocyanidins on enteroendocrine secretions in the gastrointestinal tract.
- Authors
Casanova-Martí, Àngela; Serrano, Joan; Blay, M Teresa; Terra, Ximena; Ardévol, Anna; Pinent, Montserrat
- Abstract
Background: Enteroendocrine cells respond to food components by secreting an array of hormones that regulate several functions. We have previously shown that grape seed proanthocyanidins (GSPE) modulate GLP-1 levels. Objective: To deepen on the knowledge of the mechanisms used by GSPE to increase GLP-1, and extend it to its role at modulation of other enterohormones. Design: We used an ex vivo system to test direct modulation of enterohormones; STC-1 cells to test pure phenolic compounds; and rats to test the effects at different gastrointestinal segments. Results: GSPE compounds act at several locations along the gastrointestinal tract modulating enterohormone secretion depending on the feeding condition. GSPE directly promotes GLP-1 secretion in the ileum, while unabsorbed/metabolized forms do so in the colon. Such stimulation requires the presence of glucose. GSPE enhanced GIP and reduced CCK secretion; gallic acid could be partly responsible for this effect. Conclusions: The activity of GSPE modulating enterohormone secretion may help to explain its effects on metabolism. GSPE acts through several mechanisms; its compounds and their metabolites are GLP-1 secretagogues in ileum and colon, respectively. In vivo GLP-1 secretion might also be mediated by indirect pathways involving modulation of other enterohormones that in turn regulate GLP-1 release.
- Subjects
ANIMAL experimentation; BIOFLAVONOIDS; CELL lines; CHOLECYSTOKININ; COLON (Anatomy); GASTROINTESTINAL system; ILEUM; PHENOLS; RATS; GLUCAGON-like peptide 1; GRAPE seed extract
- Publication
Food & Nutrition Research, 2017, Vol 61, Issue 1, pN.PAG
- ISSN
1654-6628
- Publication type
Article
- DOI
10.1080/16546628.2017.1321347