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- Title
Nephro-protective effect of vitamin C and Nigella sativa oil on gentamicin associated nephrotoxicity in rabbits.
- Authors
Saleem, Uzma; Ahmad, Bashir; Rehman, Kanwal; Mahmood, Saeed; Alam, Maqsood; Erum, Alia
- Abstract
Oxidative stress causes the generation of reactive oxygen species (ROS) that lead to nephrotoxicity. An aminoglycoside, gentamicin, has pronounced nephrotoxic effect in humans and animals and this study was planned to observe the nephro-protective effect of antioxidants, vitamin C and Nigella sativa oil. Serum creatinine, blood urea nitrogen, and antioxidant activity were measured as indicators of nephrotoxicity for all the groups of rabbits. Results showed that vitamin C and Nigella sativa oil both had nephro-protective effect as they lowered the values of nephrotoxicity indicators (serum creatinine, blood urea nitrogen, and antioxidant activity) as compared to gentamicin control group values. When these two antioxidants were given as combination, they proved to have synergistic nephroprotective effect.
- Subjects
THERAPEUTIC use of vitamin C; BLACK cumin; GENTAMICIN; NEPHROTOXICOLOGY; OXIDATIVE stress; REACTIVE oxygen species; LABORATORY rabbits
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2012, Vol 25, Issue 4, p727
- ISSN
1011-601X
- Publication type
Article