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- Title
Post-weaning social isolation of rats induces reduction in the gene expression of vascular endothelial growth factor (VEGF) in the hippocampus.
- Authors
Chmelova, Magdalena; Jezova, Daniela; Riecansky, Igor; Hlavacova, Natasa
- Abstract
The role of vascular endothelial growth factor (VEGF) in chronic stress and neurodevelopmental disorders is of growing research interest. Here we show that post-weaning isolation rearing of rats decreased gene expression of VEGF in the hippocampus. Gene expression of VEGF upstream regulator fibroblast growth factor-2 (FGF-2) or its downstream mediator endothelial nitric oxide synthase (eNOS) was unchanged. Other signaling pathways appear to be involved in isolationinduced reduction in VEGF gene expression. Sex differences in VEGF and eNOS gene expression with significantly higher mRNA levels in females than males were revealed.
- Subjects
VASCULAR endothelial growth factors; HIPPOCAMPUS (Brain); FIBROBLAST growth factor 2; NITRIC-oxide synthases; MESSENGER RNA
- Publication
General Physiology & Biophysics, 2019, Vol 38, Issue 4, p365
- ISSN
0231-5882
- Publication type
Article
- DOI
10.4149/gpb_2019019