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- Title
Decreased flow-mediated dilatation in patients with rheumatoid arthritis: a meta-analysis.
- Authors
Shu-Zhen Xu; Peng Wang; Shi-Yang Guan; Hong-Miao Li; Rui-Xue Leng; Hai-Feng Pan; Dong-Qing Ye; Xu, Shu-Zhen; Wang, Peng; Guan, Shi-Yang; Li, Hong-Miao; Leng, Rui-Xue; Pan, Hai-Feng; Ye, Dong-Qing
- Abstract
<bold>Objectives: </bold>To derive a more precise comparison of flow-mediated dilatation (FMD%) of the brachial artery between patients with rheumatoid arthritis (RA) and normal controls by performing a meta-analysis of appropriate studies.<bold>Methods: </bold>PubMed and EMBASE databases were searched for all relevant articles. STATA (V.12.0) software was used to perform the meta-analysis. Quality estimation of all appropriate studies was evaluated according to the Newcastle-Ottawa Scale (NOS). Standardised mean difference (SMD) with 95% CIs were calculated with a random-effects model. The Cochrane Q test and I2 statistic were used to evaluate the heterogeneity. Funnel plot and Egger's test were conducted to assess the publication bias.<bold>Results: </bold>In total, 464 articles were obtained after searching the two databases. Ten studies were included in the meta-analysis on the basis of the inclusion and exclusion criteria. Significant heterogeneity was observed among these 10 studies (Q=102.89, p<0.001, I2=91.3%) with random-effects modelling. The results showed that the RA group had significantly lower FMD% (SMD: -1.405; 95% CI -1.992 to -0.817; p<0.001) than the control group. Egger's test (p=0.004) indicated that the funnel plot showed a skewed or asymmetrical shape and publication bias existed. Sensitivity analyses suggested the robustness and credibility of our results.<bold>Conclusions: </bold>FMD% in patients with RA is significantly decreased compared with healthy controls. FMD% is an important early marker of atherosclerosis. It may be used as a parameter to forecast cardiovascular disease in patients with RA.
- Subjects
BRACHIAL artery; RHEUMATOID arthritis; META-analysis; COMPUTER software; HETEROGENEITY; BLOOD flow measurement; VASODILATION; VASCULAR diseases; COMPARATIVE studies; HEMODYNAMICS; RESEARCH methodology; MEDICAL cooperation; RESEARCH; RISK assessment; SYSTEMATIC reviews; EVALUATION research
- Publication
Postgraduate Medical Journal, 2017, Vol 93, Issue 1099, p260
- ISSN
0032-5473
- Publication type
journal article
- DOI
10.1136/postgradmedj-2016-134068