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- Title
EDUC'AVK: reduction of oral anticoagulant-related adverse events after patient education: a prospective multicenter open randomized study.
- Authors
Pernod, Gilles; Labarère, José; Yver, Jacqueline; Satger, Bernadette; Allenet, Benoit; Berremili, Touffek; Fontaine, Michèle; Franco, Guy; Bosson, Jean; Labarère, José; Fontaine, Michèle; Bosson, Jean Luc
- Abstract
<bold>Background: </bold>Long-term oral anticoagulation treatment is associated with potential morbidity. Insufficient patient education is linked to poorly controlled anticoagulation. However the impact of a specific educational program on anticoagulation related morbidity remains unknown.<bold>Objective: </bold>To evaluate the effect of an oral anticoagulation patient education program in reducing both hemorrhagic and recurrent thrombotic complications.<bold>Design/participants: </bold>We conducted a prospective, multicenter open randomized study, comparing an interventional group who received a specific oral anticoagulation treatment educational program with a control group. Eligible patients were older than 18 and diagnosed as having deep vein thrombosis or pulmonary embolism requiring therapy with a vitamin K antagonist for 3 months or more. Our primary outcome was the occurrence of hemorrhagic or thromboembolic events.<bold>Results: </bold>During the 3-month follow-up the main outcome criteria were observed 20 times (6.6% of patients), 5 (3.1%) in the experimental and 15 (10.6%) in the control group. Consequently, in multivariate analysis, the cumulative risk reduction in the experimental group was statistically significant (OR 0.25, 95% CI 0.1-0.7, p < 0.01).<bold>Conclusions: </bold>Patient education using an educational program reduced VKA-related adverse event rates.
- Subjects
DISEASES; DRUG side effects; PATIENT education; HEMORRHAGE; BLOOD coagulation disorders
- Publication
JGIM: Journal of General Internal Medicine, 2008, Vol 23, Issue 9, p1441
- ISSN
0884-8734
- Publication type
journal article
- DOI
10.1007/s11606-008-0690-1