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- Title
Asymmetric Dearomatization of β-Naphthols through an Amination Reaction Catalyzed by a Chiral Phosphoric Acid.
- Authors
Wang, Shou‐Guo; Yin, Qin; Zhuo, Chun‐Xiang; You, Shu‐Li
- Abstract
A highly efficient catalytic asymmetric dearomatization of naphthols by means of an electrophilic amination reaction catalyzed by chiral phosphoric acid is presented. This protocol provides a facile access to functionalized β-naphthalenone compounds with a chiral quaternary carbon center in excellent yields and enantioselectivity (up to 99 % yield, up to 96 % ee).
- Subjects
AROMATIZATION; AMINATION; PHOSPHORIC acid; ELECTROPHILES; ENANTIOSELECTIVE catalysis
- Publication
Angewandte Chemie International Edition, 2015, Vol 54, Issue 2, p647
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201409756