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- Title
Cytoprotective Alginate/Polydopamine Core/Shell Microcapsules in Microbial Encapsulation.
- Authors
Kim, Beom Jin; Park, Taegyun; Moon, Hee Chul; Park, So‐Young; Hong, Daewha; Ko, Eun Hyea; Kim, Ji Yup; Hong, Jong Wook; Han, Sang Woo; Kim, Yang‐Gyun; Choi, Insung S.
- Abstract
Chemical encapsulation of microbes in threedimensional polymeric microcapsules promises various applications, such as cell therapy and biosensors, and provides a basic platform for studying microbial communications. However, the cytoprotection of microbes in the microcapsules against external aggressors has been a major challenge in the field of microbial microencapsulation, because ionotropic hydrogels widely used for microencapsulation swell uncontrollably, and are physicochemically labile. Herein, we developed a simple polydopamine coating for obtaining cytoprotective capability of the alginate capsule that encapsulated Saccharomyces cerevisiae. The resulting alginate/ polydopamine core/shell capsule was mechanically tough, prevented gel swelling and cell leakage, and increased resistance against enzymatic attack and UV-C irradiation. We believe that this multifunctional core/shell structure will provide a practical tool for manipulating microorganisms inside the microcapsules.
- Subjects
ENCAPSULATION (Catalysis); CELLULAR therapy; BIOSENSORS; ALGINATES; DOPAMINE
- Publication
Angewandte Chemie International Edition, 2014, Vol 53, Issue 52, p14443
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201408454