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- Title
Combined Diagnosis of SARS-CoV-2: Rapid Antigen Detection as an Adjunct to Nucleic Acid Detection.
- Authors
Li, Xuewen; Wang, Yiting; Pan, Junqi; Xu, Jiancheng; Zhou, Qi
- Abstract
Coronavirus disease 2019 is a serious threat to human life, and early diagnosis and screening can help control the COVID-19 pandemic. The high sensitivity of reverse transcriptase–polymerase chain reaction (RT-PCR) assay is the gold standard for the diagnosis of COVID-19, but there are still some false-negative results. Rapid antigen detection (RAD) is recommended by the World Health Organization (WHO) as a screening method for COVID-19. This review analyzed the characteristics of RDT and found that although the overall sensitivity of RAD was not as high as that of RT-PCR, but RAD was more sensitive in COVID-19 patients within 5 days of the onset of symptoms and in COVID-19 patients with Ct ≤ 25. Therefore, RAD can be used as an adjunct to RT-PCR for screening patients with early COVID-19. Finally, this review provides a combined diagnostic protocol for RAD and nucleic acid testing with the aim of providing a feasible approach for COVID-19 screening.
- Subjects
CLINICAL pathology; REVERSE transcriptase polymerase chain reaction; COVID-19; IMMUNOLOGY technique; MEDICAL screening; EPIDEMICS; SENSITIVITY &; specificity (Statistics); ANTIGENS; NUCLEIC acids
- Publication
Laboratory Medicine, 2023, Vol 54, Issue 2, pe37
- ISSN
0007-5027
- Publication type
Article
- DOI
10.1093/labmed/lmac089