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- Title
Diagnosis and treatment of thrombotic microangiopathy.
- Authors
Thompson, Gemma L.; Kavanagh, David
- Abstract
Thrombotic microangiopathy (TMA) is characterized by thrombocytopenia, microangiopathic haemolytic anaemia and end organ damage. TMAs have varying underlying pathophysiology and can therefore present with an array of clinical presentations. Renal involvement is common as the kidney is particularly susceptible to the endothelial damage and microvascular occlusion. TMAs require rapid assessment, diagnosis, and commencement of appropriate treatment due to the high morbidity and mortality associated with them. Ground‐breaking research into the pathogenesis of TMAs over the past 20 years has driven the successful development of targeted therapeutics revolutionizing patient outcomes. This review outlines the clinical presentations, pathogenesis, diagnostic tests and treatments for TMAs.
- Subjects
THROMBOTIC thrombocytopenic purpura treatment; HEMOLYTIC-uremic syndrome diagnosis; HEMOLYTIC-uremic syndrome treatment; THROMBOTIC thrombocytopenic purpura; HEMOLYTIC-uremic syndrome; SYMPTOMS
- Publication
International Journal of Laboratory Hematology, 2022, Vol 44, p101
- ISSN
1751-5521
- Publication type
Article
- DOI
10.1111/ijlh.13954