We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Total Synthesis of Notoamides F, I, and R and Sclerotiamide.
- Authors
Zhang, Benxiang; Zheng, Weifeng; Wang, Xiaoqing; Sun, Deqian; Li, Chaozhong
- Abstract
The total synthesis of the natural indole alkaloids (+)-notoamide F, I, and R and (−)-sclerotiamide is described. The four heptacyclic compounds were synthesized in 10-12 steps in a convergent and highly stereoselective manner from the readily available Seebach acetal. Key steps of the synthesis include a stereoselective oxidative aza-Prins cyclization to construct the bicyclo[2.2.2]diazaoctane, and a cobalt-catalyzed radical cycloisomerization to create the cyclohexenyl ring.
- Subjects
INDOLE alkaloid synthesis; AMIDE synthesis; CYCLIC compounds; STEREOSELECTIVE reactions; RING formation (Chemistry); COBALT catalysts; CYCLOISOMERIZATION; CYCLOHEXENYL compounds
- Publication
Angewandte Chemie International Edition, 2016, Vol 55, Issue 35, p10435
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201604754