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- Title
Chelator-Free Synthesis of a Dual-Modality PET/MRI Agent.
- Authors
Chen, Feng; Ellison, Paul A.; Lewis, Christina M.; Hong, Hao; Zhang, Yin; Shi, Sixiang; Hernandez, Reinier; Meyerand, M. Elizabeth; Barnhart, Todd E.; Cai, Weibo
- Abstract
Old technique, new application: A simple and efficient chelator‐free strategy for the synthesis of a novel dual‐modality PET/MRI agent has been developed. Labeling of radioarsenic (*AsIII and *AsV, *=71, 72, 74, 76) at the surface of superparamagnetic iron oxide nanoparticles (SPIONs) resulted in *As‐SPIONs that can be used for simultaneous PET/MRI in cancer diagnosis, lymph‐node mapping, and potentially for internal radiotherapy.
- Subjects
IRON chelate synthesis; CHELATES; POSITRON emission tomography; MAGNETIC resonance imaging; ARSENIC compound synthesis
- Publication
Angewandte Chemie International Edition, 2013, Vol 52, Issue 50, p13319
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201306306