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- Title
Immunocytochemical localization of α-actinin in frog muscle treated with the ionophore A23187.
- Authors
Llados, Fernando T.; Kriho, Virginia; Pappas, George D.
- Abstract
Incubation of frog skeletal muscle with the ionophore A23187 induces severe damage in the muscle. At the level of the Z line, the ionophore induces redistribution and release of the protein α-actinin, as shown by immunocytochemical techniques. The ionophore does not induce damage in denervated preparations or in preparations pretreated with d-tubocurarine, which indicates that the effect is indirect and neurally mediated. It is concluded that the increase in spontaneous transmitter release produced by the ionophore induces Ca2+ influx through the acetylcholine receptor. Calcium ions activate neutral proteases which release α-actinin from the Z line.
- Publication
Muscle & Nerve, 1988, Vol 11, Issue 9, p953
- ISSN
0148-639X
- Publication type
Article
- DOI
10.1002/mus.880110908