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- Title
UTICAJ NOVIH INHIBITORA SINTAZE AZOTNOG OKSIDA NA SPONTANU LOKOMOTORNU AKTIVNOST.
- Authors
Džoljić, Eleonora; Nešic, Zorica; Stojanović, Radan; Vučković, Sonja; Todorović, Zoran; Prostran, Milica
- Abstract
Introduction. New nitric oxide synthase (NOS) inhibitors: 3-bromo-7-nitro- indazole (3-Br-7-NI), 1-(2-trifluoromethylphenyl) imidazole (TRIM), S-methyl-L-thiocitrulline (S-Me-TC) and 7-nitroindazole (7-NI) reduce spontaneous locomotor activity in mice. Material and methods. In order to elucidate central effects of NOS inhibitors on locomotor activity, the influence of 7-NI on electroencephalographic (EEG) power spectrum in rats was investigated. Results. 7-NI reduced the EEG power density in all frequency bands in rats, suggesting a depression of the central neuronal activity. The electrophysiologic power was most reduced in the range of 7-9 Hz of the rhythmic slow activity (theta rhythm), which is in accordance with decreased locomotor activity observed following administration of NOS inhibitors. Conclusion. The present results indicate that nitric oxide exerts an excitatory effect on central neuronal structures involved in regulation of locomotion.
- Subjects
NITRIC oxide; IMIDAZOLES; MUSCULOSKELETAL system; LABORATORY mice; ELECTROENCEPHALOGRAPHY; ELECTROPHYSIOLOGY
- Publication
Medical Review / Medicinski Pregled, 2006, Vol 59, Issue 9/10, p436
- ISSN
0025-8105
- Publication type
Article
- DOI
10.2298/MPNS0610436D