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- Title
Graft versus Host Disease: Cases from New Zealand with Oral Manifestations.
- Authors
K. E., McElroy; B. L., Seo; H. M., Hussaini; A. M., Rich
- Abstract
Background and objectives: In recent decades increasing numbers of haematopoietic stem cell transplants have been undertaken for the treatment of various haematological conditions. Increased use of allogeneic transplants, in particular those utilising peripheral blood stem cell transplants (PBSCT) is likely to result in an increased burden of graft versus host disease (GvHD) associated with transplantation. Survivors are living for longer, and dentists are therefore likely to see more patients presenting with the chronic manifestations of this disease. Oral manifestations of GvHD are not uncommon, and carry a high burden of morbidity. This paper documents cases reported as GvHD in the Oral Pathology Centre (OPC) in the Faculty of Dentistry, the University of Otago in the last two decades. Methods: A computerised search of the OPC database for the period spanning from 1 January 2000 to 30 June 2019 was undertaken to identify cases diagnosed as GvHD. Results: Five cases from a total of 31,024 accessions in the time period were identified from the database that were diagnosed as 'possible GvHD' or 'likely GvHD'. These consisted of four males and one female, with an average age (at time of biopsy) of 55 years. Conclusions: Whilst biopsy of the oral cavity for the diagnosis of oral GvHD is not common, GvHD often presents orally and prompt clinical recognition is important. Immunosuppressive therapy is the mainstay of treatment for GvHD and has clear implications for dental management. Dentists have a duty of care to review these patients regularly to assist in the maintenance of excellent oral health and to check for the development of secondary malignancy in the oral region, due to the increased risk of oral squamous cell carcinoma development.
- Subjects
NEW Zealand; GRAFT versus host disease; UNIVERSITY of Otago; MOUTH; STEM cell transplantation; SQUAMOUS cell carcinoma; ORAL manifestations of general diseases; ORAL health
- Publication
New Zealand Dental Journal, 2020, Vol 116, Issue 2, p47
- ISSN
0028-8047
- Publication type
Article