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- Title
S-100 protein in tumors of cartilage and bone. An immunohistochemical study.
- Authors
Nakamura, Yasuhiro; Becker, Laurence E.; Marks, Alexander; Nakamura, Y; Becker, L E; Marks, A
- Abstract
Using the peroxidase-antiperoxidase (PAP) immunohistochemical method, S-100 protein was found in well-differentiated chondrocytes of chondroma, chondroblastoma, mesenchymal chondrosarcoma, and osteosarcoma. It was not detected in osteoma, osteoblastoma, giant cell tumor, and Ewing's tumor. The presence of S-100 protein in tumorous chondrocytes and chondroblasts suggests that this protein may be a marker of chondrocyte origin and should not be considered a specific marker for nerve tissue.
- Subjects
OSTEOSARCOMA; BONE tumors; CYTOCHEMISTRY; CANCER; IMMUNOENZYME technique; CHONDROSARCOMA; CALCIUM-binding proteins; FEMUR; CONNECTIVE tissue tumors; ENCHONDROMA
- Publication
Cancer (0008543X), 1983, Vol 52, Issue 10, p1820
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19831115)52:10<1820::AID-CNCR2820521010>3.0.CO;2-3