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- Title
Human leukemic "null" cell line (NALL-1).
- Authors
Hiraki, Shunkichi; Miyoshi, Isao; Kubonishi, Ichiro; Matsuda, Yuzo; Nakayama, Takashi; Kishimoto, Hirofumi; Masuji, Hiroshi; Hiraki, S; Miyoshi, I; Kubonishi, I; Matsuda, Y; Nakayama, T; Kishimoto, H; Masuji, H
- Abstract
A human lymphoblast cell line, NALL-1, was established from the peripheral blood of a patient with acute lymphoblastic leukemia (ALL). NALL-1 cells had neither properties of T and B cells nor Epstein-Barr virus (EBV). Many characteristics of the NALL-1 line were distinct from those of numerous EBV-positive lymphoblastoid cell lines previously reported. NALL-1 cells are considered to have originated from the donor's leukemic cells on the basis of their cytogenetic, morphologic and functional features. The NALL-1 line is the first human leukemic "null" cell line derived from ALL. The significance of this cell line is disscussed.
- Publication
Cancer (0008543X), 1977, Vol 40, Issue 5, p2131
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(197711)40:5<2131::AID-CNCR2820400523>3.0.CO;2-V