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- Title
Aerobic exercise improves postprandial inflammatory and hemostatic markers after a high-fat meal: a randomized crossover study.
- Authors
Teixeira, Bruno Costa; Krüger, Renata Lopes; Farinha, Juliano Boufleur; Boeno, Franccesco Pinto; Macedo, Rodrigo Cauduro Oliveira; Fonseca, Gabriel Alves; Bandinelli, Eliane; Duarte, Marta Maria Medeiros Frescura; Reischak-Oliveira, Alvaro
- Abstract
Exercise intensity modulates postprandial lipemia. However, its effect on hemostatic and pro- and anti-inflammatory markers in the postprandial state is still unknown. Eleven young males performed a 2-day trial on different conditions: (i) REST: rest for 45 min; (ii) MIE: moderate-intensity exercise; and (iii) HIE: heavy-intensity exercise. Experimental conditions were performed in the evening. On the following morning, blood samples were taken in the fasted state (0 h) and at 1, 3, and 5 h after the consumption of a high-fat meal (HFM). Interleukin-10 (IL-10) levels were higher in the HIE vs. MIE trial at 0 and 1 h (p < 0.033) and IL-10 incremental area under the curve (iAUC) was greater in the MIE (p = 0.027) and HIE (p = 0.045) trials vs. REST. Lower levels of anti-coagulation factor VII (FVII) were observed at 1 h in the MIE condition vs. REST (p = 0.043). In comparison with REST, MIE improved hemostatic (FVII) and anti-inflammatory markers (IL-10 iAUC) whereas HIE enhanced IL-10 in the postprandial state. Regardless of the exercise intensity, aerobic exercise mitigates the deleterious consequences of an HFM. Novelty: Prior aerobic exercise at moderate-intensity attenuates next day's postprandial FVII and IL-10 levels whereas exercise performed at heavy-intensity increases IL-10 levels. Moderate-intensity exercise may be more beneficial to improve hemostatic (FVII) and anti-inflammatory (IL-10) responses while heavy-intensity exercise may improve anti-inflammatory (IL-10) levels only.
- Subjects
INFLAMMATION prevention; BIOMARKERS; FASTING; INTERLEUKINS; AEROBIC exercises; FAT content of food; INGESTION; HEMOSTASIS; BLOOD collection; TREATMENT effectiveness; RANDOMIZED controlled trials; HYPERLIPIDEMIA; EXERCISE intensity; CROSSOVER trials; STATISTICAL sampling; BLOOD coagulation factors; TISSUE plasminogen activator
- Publication
Applied Physiology, Nutrition & Metabolism, 2021, Vol 46, Issue 6, p637
- ISSN
1715-5312
- Publication type
Article
- DOI
10.1139/apnm-2020-0463