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- Title
Interaction of Interferons with Skin Reactive Cytokines: from Interleukin-1 to Interleukin-8.
- Authors
Damme, Jo Van; Opdenakker, Ghislain
- Abstract
The skin as an organ contains a large pool of cells, important for the production of various cytokines. This study focuses on interferon-β (IFN-β), interleukin-6 (IL-6), and interleukin-8 (IL-8) production by fibroblasts and epithelial cells in response to interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-α). Both these primary cytokines show multiple biologic activities in the skin. Their antiviral activity on fibroblasts is mediated by IFN-β and not by IL-6. In addition, TNF-α and IL-β 1 have a growth stimulatory effect on dermal fibroblasts, which is not mediated by IFN-β or IL-6. IL-1, double-stranded RNA, or virus are potent inducers of IL-6 and IL-8 on dermal fibroblasts, but they are less efficient on epidermal cells. IL-8 has been discovered as an early acting skin reactive factor responsible for the chemotaxis of neutrophilic granulocytes. Furthermore, IL-1 possesses delayed skin reactivity upon intradermal injection which presumably is mediated by local release of IL-8. These findings demonstrate that cytokines also interact in the skin and that dermal fibroblasts play an important role in the regulation of aspecific host defense.
- Subjects
INTERFERONS; CYTOKINES; INTERLEUKINS; ORGANS (Anatomy); FIBROBLASTS; GRANULOCYTES; RNA
- Publication
Journal of Investigative Dermatology, 1990, Vol 95, p90S
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1111/1523-1747.ep12874825