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- Title
Risk of developing a second primary cancer in male breast cancer survivors: a systematic review and meta-analysis.
- Authors
Allen, Isaac; Hassan, Hend; Sofianopoulou, Eleni; Eccles, Diana; Turnbull, Clare; Tischkowitz, Marc; Pharoah, Paul; Antoniou, Antonis C.
- Abstract
<bold>Background: </bold>With increasing survival after cancer diagnoses, second primary cancers (SPCs) are becoming more prevalent. We investigated the incidence and site of non-breast SPC risks following male breast cancer (BC).<bold>Methods: </bold>PubMed, Embase and Web of Science were systematically searched for studies reporting standardised incidence ratios (SIRs) for SPCs published by March 2022. Meta-analyses used the generic inverse-variance method, assuming a random-effects model. We evaluated SIRs for overall SPCs, site-specific risks, by age at BC onset, time since BC onset and geographic region. We assessed study quality using routine techniques.<bold>Results: </bold>Eight population-based retrospective cohort studies were identified. SIRs ranged from 1.05 to 2.17. The summary SIR estimate was 1.27 (95% CI: 1.03-1.56, I2: 86%), and there were increased colorectal (SIR: 1.29, 95% CI: 1.03-1.61), pancreatic (SIR: 1.64, 95% CI: 1.05-2.55) and thyroid (SIR: 5.58, 95% CI: 1.04-30.05) SPC risks. When an outlying study was excluded, the summary SIR for men diagnosed with BC before age 50 was 1.50 (95% CI: 1.21-1.85), significantly higher than men diagnosed at older ages (SIR: 1.14, 95% CI: 0.98-1.33).<bold>Conclusions: </bold>Male BC survivors are at elevated risks of developing second primary colorectal, pancreatic and thyroid cancers. The estimates may assist their clinical management and guide decisions on genetic testing.
- Subjects
RESEARCH; FERRANS &; Powers Quality of Life Index; META-analysis; RESEARCH methodology; DISEASE incidence; RETROSPECTIVE studies; EVALUATION research; MALE breast cancer; COLORECTAL cancer; COMPARATIVE studies; SECONDARY primary cancer; RESEARCH funding; DISEASE complications
- Publication
British Journal of Cancer, 2022, Vol 127, Issue 9, p1660
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/s41416-022-01940-1