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- Title
Accumulation of Tritium and Other Undesirable β-Emitting Radionuclides in the Production of Radiopharmaceuticals for PET Diagnostics.
- Authors
Brinkevich, S. D.; Brinkevich, D. I.; Kiyavitskaya, H. I.; Kiyko, A.N.
- Abstract
The article deals with the problem of formation of undesirable β-emitting radionuclides (RNs) in the production of radiopharmaceuticals for PET diagnostics. It is found that tritium is the main trace RN formed by the reaction 18O(p,t)16O during irradiation of water [18O]H2O with protons. Other trace β emitters in water accumulate mainly as a result of leaching of activated target wall materials. The possibility of using the activity of tritium in water [18O]H2O as an indicator of its re-enrichment is shown. The necessity of controlling the content of trace β-emitting RNs in intermediate products, production waste, and final radiopharmaceuticals is demonstrated.
- Subjects
RADIOPHARMACEUTICALS; RADIOISOTOPES; NURSES; TRITIUM; IRRADIATION; LEACHING; PROTONS; CYCLOTRONS
- Publication
Physics of Atomic Nuclei, 2023, Vol 86, Issue 9, p2130
- ISSN
1063-7788
- Publication type
Article
- DOI
10.1134/S1063778823100101