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- Title
Long-term administration of 3′-Azido-2′,3′-dideoxythymidine to patients with AIDS-related neurological disease.
- Authors
Yarchoan, Robert; Thomas, Rose V.; Grafman, Jordan; Wichman, Alison; Dalakas, Marinos; McAtee, Nanette; Berg, Gary; Fischl, Margaret; Perno, Carlo Federico; Klecker, Raymond W.; Buchbinder, Aby; Tay, Steven; Larson, Steven M.; Myers, Charles E.; Broder, Samuel
- Abstract
3′-Azido-2′,3′-dideoxythymidine (AZT) has been administered to 7 patients with human immunodeficiency virus associated neurological disease: 3 with dementia, 2 with peripheral neuropathy, 1 with dementia and peripheral neuropathy, and 1 with T-10 paraplegia. Six of the patients showed improvement in their neurological dysfunction on being administered AZT, as assessed by clinical evaluation, neuropsychological testing, nerve conduction studies, and/or positron emission tomographic scans. Three of these 6 patients showed sustained improvement 5 to 18 months after the initiation of AZT therapy. These results suggest that certain human immunodeficiency virus-associated neurological abnormalities are at least partially reversible following the administration of antiretroviral therapy and provide a rationale for further studies using antiretroviral chemotherapy.
- Publication
Annals of Neurology, 1988, Vol 23, Issue S1, pS82
- ISSN
0364-5134
- Publication type
Article
- DOI
10.1002/ana.410230722