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- Title
Common variation at 10p12.31 near MLLT10 influences meningioma risk.
- Authors
Dobbins, Sara E.; Broderick, Peter; Melin, Beatrice; Feychting, Maria; Johansen, Christoffer; Andersson, Ulrika; Brännström, Thomas; Schramm, Johannes; Olver, Bianca; Lloyd, Amy; Ma, Yussanne P; Hosking, Fay J.; Lönn, Stefan; Ahlbom, Anders; Henriksson, Roger; Schoemaker, Minouk J.; Hepworth, Sarah J.; Hoffmann, Per; Mühleisen, Thomas W.; Nöthen, Markus M.
- Abstract
To identify susceptibility loci for meningioma, we conducted a genome-wide association study of 859 affected individuals (cases) and 704 controls with validation in two independent sample sets totaling 774 cases and 1,764 controls. We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, Pcombined = 1.88 × 10?14). This finding advances our understanding of the genetic basis of meningioma development.
- Subjects
MENINGIOMA; BRAIN tumor genetics; GENOMES; NEUROFIBROMATOSIS; LOCUS (Genetics); DISEASE risk factors
- Publication
Nature Genetics, 2011, Vol 43, Issue 9, p825
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.879