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- Title
Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.
- Authors
Graham, Robert R.; Cotsapas, Chris; Davies, Leela; Hackett, Rachel; Lessard, Christopher J.; Leon, Joanlise M.; Burtt, Noel P.; Guiducci, Candace; Parkin, Melissa; Gates, Casey; Plenge, Robert M.; Behrens, Timothy W.; Wither, Joan E.; Rioux, John D.; Fortin, Paul R.; Graham, Deborah Cunninghame; Wong, Andrew K.; Vyse, Timothy J.; Daly, Mark J.; Altshuler, David
- Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease influenced by genetic and environmental factors. We carried out a genome-wide association scan and replication study and found an association between SLE and a variant in TNFAIP3 (rs5029939, meta-analysis P = 2.89 × 10−12, OR = 2.29). We also found evidence of two independent signals near TNFAIP3 associated with SLE, including one previously associated with rheumatoid arthritis (RA). These results establish that variants near TNFAIP3 contribute to differential risk of SLE and RA.
- Subjects
SYSTEMIC lupus erythematosus; AUTOIMMUNE diseases; SKIN diseases; VASCULAR diseases; META-analysis; RHEUMATOID arthritis
- Publication
Nature Genetics, 2008, Vol 40, Issue 9, p1059
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.200