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- Title
Dissection of the Role of CD3γ Chains in Profound but Reversible T-Cell Receptor Down-regulation.
- Authors
Rubin; Llobera; Gouaillard; Alcover; Arnaud
- Abstract
T-lymphocyte activity in the immune system is regulated by the quantity of surface membrane T-cell antigen receptors (TCR). The amount of surface-bound TCR is dependent on the rate of [<BBR>1] biosynthesis, assembly and intracellular transport of the individual chains composing the TCR/CD3 complex and [<BBR>2] the internalization and recycling of the receptors. The TCR–ligand interaction augments receptor internalization. In the present paper, we have studied short- and long-term down-regulation of TCR/CD3 complexes with monoclonal anti-TCR/CD3 antibodies, and attempted to determine which component(s) of the TCR/CD3 complex are responsible for these two phenomena. Our data indicate that short- and long-term down-regulation is mediated by different mechanisms, and that the extracellular and/or transmembrane regions of CD3γ molecules appear to play an important role in chronic TCR/CD3 down-regulation and subsequent deficient re-expression. These results may have important implications for the understanding of induction of T-cell tolerance or anergy.
- Subjects
T cell receptors; RECEPTOR-ligand complexes; IMMUNE response
- Publication
Scandinavian Journal of Immunology, 2000, Vol 52, Issue 2
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1046/j.1365-3083.2000.00767.x