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- Title
Phenotypic Characterization of Splenic T Cells from Mice Infected with <em>Plasmodium chabaudi chabaudi</em>.
- Authors
Langhorne, J.; Pells, S.; Eichmann, K.
- Abstract
T cells from spleens of mice infected with the erythrocytic stages of Plasmodium chabaudi chabaudi have been analysed with respect to their expression of surface molecules CD3, CD4 and CD8 and T-cell receptor (TCR)αβ and γδ. The majority of T cells from infected mice were αβTCR+ . However, there was an increase of approximately 8-10-fold in the proportion and total number of γδ5 T cells. Immunocytochemical analysis of sections of spleens taken from infected C57BL/6 mice during a primary infection showed that this increase took place particularly in the non-lymphoid areas. Within the TCRαβ T-cell population, both CD4+ T cells and CD8+ T cells were represented in proportions similar to those observed in normal uninfected mice. Stimulation of splenic T cells from infected mice with P. chabaudi-infected erythrocytes in vitro resulted in a blasted cell population composed predominantly of αβTCR+ T cells with no preferential expansion of γδTCR+ T cells. There was no evidence of superantigen-like stimulation of T cells bearing particular Vβ chains of the TCR. The representation of the different Vβ chains within the population was not significantly different from that seen in uninfected mice.
- Subjects
PHENOTYPES; T cell receptors; PLASMODIUM; MOLECULES; IMMUNOCYTOCHEMISTRY; LABORATORY mice
- Publication
Scandinavian Journal of Immunology, 1993, Vol 38, Issue 6, p521
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1993.tb03235.x