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- Title
Repopulation Potential of Thymocytes Forming Rosettes with Phagocytic Cells of the Thymic Reticulum.
- Authors
El Rouby, S.; Ezine, S.; Papiernik, M.
- Abstract
Thymocytes binding in vitro to phagocyte cells of the thymic reticulum (P-TR), termed ‘rosetting thymocytes’, were injected intravenously into irradiated congenic mice and their migration patterns were compared with those that do not bind to P-TR, called ‘non-rosetting thymocytes’, similarly transferred. Donor cells, C57BL/Ka Thy 1.2, were distinguished from recipient cells. C57BL/Ka Thy 1.1 by a direct immunofluorescence technique using an anti-Thy 1.2 monoclonal antibody. The result demonstrate that the resetting thymocytes have a greater capacity for homing back to the thymus and for populating the mesenteric lymph node and the spleen. Intrathymic transfer assay revealed that the donor-derived cells detected in the peripheral organs were of thymic origin.
- Subjects
PHAGOCYTES; IMMUNE system; RETICULUM cell sarcoma; MONOCLONAL antibodies; THYMIC hormones; IMMUNE response; IMMUNE complexes
- Publication
Scandinavian Journal of Immunology, 1988, Vol 27, Issue 4, p433
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1988.tb02368.x