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- Title
Two Distinct Azobenzenearsonate-Specific Helper T-Cell Subpopulations Mediate Different Forms of T-B Cooperation.
- Authors
Adorini, L.; Agarossi, G.; Fioravanti, D.; Doria, G.
- Abstract
Popliteal lymph node T cells from mice footpad-primed with azobenzenearsonate (ABA)-protein conjugates were able to help the anti-trinitrophenyl (TNP) and anti-ABA plaque-forming cell (PFC) responses of normal syngeneic spleen cells cultured in vitro with TNPABA- keyhole limpet haemocyanin. Enrichment in ABA-specific helper cells was obtained by positive selection of ABA-primed T cells on ABA-pulsed syngeneic macrophages. The ABA-specific T cells induced by ABA-protein priming are able to help the anti-TNP PFC response of normal B cells through recognition of the ABA determinant either unlinked to TNP (ABA and TNP separately presented to T and B cells) or linked to TNP (ABA and TNP presented as moieties of the same molecule). These two mechanisms of T-B cooperation are mediated by two different ABA-specific helper T-cell subpopulations, which can be distinguished by their different radiosensitivities: the former mechanism is mediated by radioresistant T cells, whereas the latter is mediated by radiosensitive T cells. Both helper T-cell subpopulations bind the ABA-pulsed syngeneic macrophages, demonstrating the presence of ABA-specific receptors on both cell types.
- Subjects
KILLER cells; LYMPH nodes; LYMPHATICS; T cells; SPLEEN; HEMATOPOIETIC system; B cells; ANTIGEN presenting cells
- Publication
Scandinavian Journal of Immunology, 1983, Vol 17, Issue 2, p99
- ISSN
0300-9475
- Publication type
Article