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- Title
An Analysis of the Lymphocytotoxic Activity Found in Sera from Patients with Hypogammaglobulinaemia.
- Authors
MacDonald, S.; Webster, A. D. B.; Platts-Mills, T. A. E.
- Abstract
Sera from 59 patients with hypogammaglobulinaemia (hypogamma) were assessed for lymphocytotoxic activity. The activity was compared with that found in sera from patients with systemic lupus erythematosus (SLE) in titre, class of antibody, target cell, and complement requirements. Sera from patients with hypogamma showed cytotoxic activity when compared with sera from normal donors; however, the activity was far less than that in sera from SLF patients. The cytotoxic titre of both hypogamma and SLE sera was greater against T cells than non-T cells. Sera showing activity could be used to sensitize lymphocytes and render them susceptible to subsequent lysis, but IgM was not detectable on the surface of the sensitized cells. Following sucrose density gradient fractionation of the sera the lymphocytotoxic activity was recovered in those fractions that contained IgM. Lymphocytotoxic activity was dependent on classical complement pathway activity. In all the experiments the hypogamma sera showed the same pattern of activity as the SLF sera, but the activity was always far weaker than that found in SLF sera. The evidence does not suggest that lymphocytotoxicity is likely to be important in the pathogenesis of hypogamma.
- Subjects
AGAMMAGLOBULINEMIA; LUPUS erythematosus; SKIN diseases; LYMPHOCYTES; BLOOD plasma; T cells
- Publication
Scandinavian Journal of Immunology, 1982, Vol 15, Issue 4, p379
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1982.tb00662.x