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- Title
Early glottic carcinoma treated by radiotherapy: Defining a population for surgical salvage.
- Authors
Smee, Robert I.; Williams, Janet R.; Broadley, Kathryn; Bridger, G.P.
- Abstract
Objectives/Hypothesis: Not all patients with early Glottis squamous cell carcinoma will be cured by radiotherapy. This is an audit of a single center's experience with those patients who fail by this approach. Study Design: This retrospective study was approved by the IRB (Institutional Review Board); eligibility criterion was patients treated between 1967 and December 2006, TIS, T1, T2 N0 SCC glottic carcinoma, with analysis occurring in 2009, and with a minimum follow-up of 2 years. Methods: The eligibility criteria for this ethics-approved study was that all patients started a course of radiotherapy for early glottic laryngeal SCC. Data included in the Larynx Cancer database includes information from the Radiation Oncology Department notes, referral letters, and follow-up information. This is categorized into patient, disease, and treatment factors. Results: Of 522 patients who commenced radiotherapy, local failure occurred in 105 patients; a salvage procedure was performed in 89, with surgery only in 83. For these 89 patients, the ultimate local control was 67%, with a larynx preservation procedure in 34%. Nodal failure occurred in 20 of the 522 patients (4%). There was a much higher failure rate in patients unfit for surgery (10/26-38%). Laryngectomy was the main salvage procedure in 55 patients. CONCLUSIONS: Early recognition of local failure following radiotherapy for early glottic carcinoma may avoid laryngectomy as a salvage procedure. Laryngoscope, 2013
- Subjects
GLOTTIS cancer; CANCER radiotherapy; SALVAGE therapy; RETROSPECTIVE studies; LARYNGECTOMY
- Publication
Laryngoscope, 2013, Vol 123, Issue 1, p171
- ISSN
0023-852X
- Publication type
Article
- DOI
10.1002/lary.23663